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MMP-9(20-707) His Tag Protein, Human

MMP-9(20-707) His Tag Protein, Human

Catalog Number: UA011314 Brand: UA BIOSCIENCE
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$351.00 SGD
$351.00 SGD
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Product Details

Product Specification


Species Human
Synonyms CLG4B, GELB, MANDP2, Gelatinase B, Matrix metalloproteinase-9
Accession P14780
Amino Acid Sequence

Ala20-Asp707 with His Tag at the C-Terminus
Expression System HEK293
Molecular Weight 80-100kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 95% SEC-HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Zhang X, Liu Z, Li Y, He J, Yang L, Yan Y, Tong S, Wang Y, Zhang T. Lead acetate (PbAc) impairs blood-brain barrier in zebrafish via MMP-9/13-induced pericyte developmental defects. Ecotoxicol Environ Saf. 2025 Oct 24;305:119250.
2.Skossyrskiy VS, Kurdina NA, Kuzovkova VS, Boot MS, Zelenchenkova PI, Popova EO, Sevyan NV, Mitrofanov AA, Prozorenko EV, Sekacheva MI, Orlova EV. Cyclooxygenase-2 as a potential therapeutic target in the treatment of chemoresistant glioblastomas. Med Oncol. 2025 Oct 25;42(12):530.

Background

Matrix metalloproteinase-9 (MMP-9, also known as 92 kDa gelatinase B) is a structurally complex key protease capable of degrading extracellular matrix components such as type IV collagen and gelatin. Secreted by various cells including neutrophils and macrophages, it plays vital roles in both normal tissue remodeling and pathological inflammatory processes. The activity of this enzyme requires precise regulation, and its overexpression can disrupt tissue homeostasis, thereby actively contributing to the pathogenesis of various diseases such as rheumatoid arthritis, multiple sclerosis, and tumor invasion. Consequently, it is regarded as a highly potential and important therapeutic target.

Picture

SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of MMP-9(20-707) His Tag Protein, Human is more than 95% determined by SEC-HPLC.

ELISA

Immobilized MMP-9(20-707) His Tag Protein, Human (Cat. No. UA011314) at 2.0μg/mL (100μL/well) can bind MMP9 Recombinant Rabbit mAb (SDT-368-16) (Cat. No. S0B2297) with EC50 of 4.03-6.00 ng/mL.