1μg (R: reducing condition, N: non-reducing condition).
Fas/TNFRSF6/CD95 Fc Chimera Protein, Cynomolgus
Fas/TNFRSF6/CD95 Fc Chimera Protein, Cynomolgus
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | FAS, ALPS1A, APO1, APT1, CD95, FAS1, FASTM, TNFRSF6, FasR |
| Accession | Q9TSN4 |
| Amino Acid Sequence | Gln26-Arg171, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 50-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >95% by RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas, also known as APO-1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is a prototypical death receptor characterized by the presence of an 80-amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant.
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SDS-PAGE
RP-HPLC
The purity of Fas/TNFRSF6/CD95 Fc Chimera, Cynomolgus is greater than 95% as determined by RP-HPLC.
