IHC shows positive staining in paraffin-embedded mouse cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Phospho-α-Synuclein (Ser129) Recombinant Rabbit mAb, PBS Only (SDT-3397)
Phospho-α-Synuclein (Ser129) Recombinant Rabbit mAb, PBS Only (SDT-3397)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Phospho-α-Synuclein (Ser129) |
| Synonyms | Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor (NACP); NACP; PARK1; SNCA |
| Location | Cytoplasm, Nucleus, Secreted, Synapse |
| Accession | P37840 |
| Clone Number | SDT-3397 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Ms, Rt |
Background
Phospho-α-Synuclein (Ser129) is the pathognomonic form of α-synuclein in which the serine at position 129 is stoichiometrically phosphorylated, a post-translational switch that converts the natively unfolded presynaptic protein into a sticky, aggregation-prone seed capable of nucleating Lewy bodies and Lewy neurites, propagating trans-synaptically between neurons, activating microglia and complement, and serving as the most specific biochemical correlate of dopaminergic neurodegeneration in Parkinson’s disease and dementia with Lewy bodies.
Picture
Picture
Immunohistochemistry
IHC shows positive staining in paraffin-embedded old mouse cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
