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CFTR Recombinant Rabbit mAb ,PBS Only(SDT-2133-154)

CFTR Recombinant Rabbit mAb ,PBS Only(SDT-2133-154)

Catalog Number: S0B2398P Application: IHC-P Reactivity: Human Conjugation: Unconjugated Brand: Starter
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Regular price $585 USD
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Product Details

Product Specification


Host Rabbit
Antigen CFTR
Synonyms Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; ABCC7
Immunogen Synthetic Peptide
Location Cell membrane, Endoplasmic reticulum membrane
Accession P13569
Clone Number SDT-2133-154
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P
Reactivity Hu
Positive Sample Human pancreas
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
IHC-P 1:250 Hu

Background

The CFTR protein, or cystic fibrosis transmembrane conductance regulator protein, is a crucial membrane protein found primarily in epithelial cells lining various organs such as the lungs, pancreas, and sweat glands. It functions as a chloride channel, regulating the movement of chloride ions across cell membranes to maintain proper fluid balance and mucus consistency. Mutations in the CFTR gene can lead to cystic fibrosis, a genetic disorder characterized by thick, sticky mucus buildup in the lungs and digestive system, causing chronic infections and impaired organ function. The CFTR protein also plays a role in regulating sodium channels and has broader implications for epithelial cell function and ion transport.

Picture

Immunohistochemistry

IHC shows positive staining in paraffin-embedded human pancreas. Anti-CFTR antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.