2μg（R: reducing conditions）
TSLP His Tag Protein, Human
TSLP His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Thymic stromal lymphopoietin |
| Accession | Q969D9 |
| Amino Acid Sequence | Try29-Gln159, with C-His tag |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 16.6 kDa Observed MW: 17-25 kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Thymic stromal lymphopoietin (TSLP) is a cytokine that plays a vital role in the immune system. It was first discovered in the thymus and is mainly produced by stromal cells. TSLP functions as a key mediator in initiating and regulating immune responses. It activates dendritic cells, which then stimulate the differentiation of T helper cells, especially Th2 cells. This leads to the release of various inflammatory cytokines, contributing to the development of allergic and inflammatory diseases. In addition, TSLP is involved in immune responses against certain pathogens. Its dysregulation has been associated with several immune - related disorders, making it an important target for therapeutic interventions in diseases like asthma and atopic dermatitis.
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SDS-PAGE
ELISA
Immobilized Human TSLP Protein, his tag at 2 μg/mL (100 μL/well) can bind Recombinant Human TSLP R (C-Fc) with EC50 of 2.8-3.6 ng/ml.
