1μg (R: reducing condition, N: non-reducing condition).
TIM1/HAVCR1 His Tag Protein, Human
TIM1/HAVCR1 His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD365; HAVCR1; HAVCR-1; HAVCRT cell immunoglobin domain and mucin domain protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIM1; TIM-1; TIM-1TIM; TIM1TIMD-1; TIMD1T-cell membrane protein 1 |
| Accession | Q96D42 |
| Amino Acid Sequence | Ser21-Gly295 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | > 95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471. |
Background
HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) or T cell immunoglobulin mucin 1 (TIM-1), is an integral membrane glycoprotein. KIM-1 is widely expressed, with the highest levels found in the kidney and testis. It is recognized as a major susceptibility gene for asthma, allergy, and autoimmunity in humans. IgA1lambda, a specific ligand of KIM-1, has been shown to have a synergistic effect in virus-receptor interactions. KIM-1 is implicated in the pathogenesis of acute kidney injury and has been confirmed as a biomarker of renal dysfunction in human urine. Additionally, KIM-1 is a novel regulatory molecule of flow-induced calcium signaling
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SDS-PAGE
SEC-HPLC
The purity of TIM1/HAVCR1 His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.
