2μg (R: reducing condition, N: non-reducing condition).
CD28 Fc Chimera Protein, Human/Cynomolgus/Rhesus macaque
CD28 Fc Chimera Protein, Human/Cynomolgus/Rhesus macaque
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$124 USD
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | CD28 Antigen，T-Cell-Specific Surface Glycoprotein CD28，CD28 Antigen (Tp44)，Tp44，CD28 Antigens，CD28 Molecule，T-Cell-Specific Surface Glycoprotein |
| Accession | P10747 |
| Amino Acid Sequence | Asn19-Pro152 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Courtemanche O, Huppé CA, Blais-Lecours P, Maranda C, Morissette MC, Blanchet MR, Dion G, Marsolais D. Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand. Int J Mol Sci. 2025 Mar 29;26(7):3197. |
Background
T-cell-specific surface glycoprotein CD28, also known as TP44, is a single-pass type I membrane protein containing one Ig-like V-type (immunoglobulin-like) domain. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals required for T cell activation. It serves as the receptor for CD80 (B7.1) and CD86 (B7.2). When antigen-presenting cells (APCs) are activated by Toll-like receptor ligands, CD80 expression is upregulated. In contrast, CD86 expression on APCs is constitutive. Notably, CD28 is the only B7 receptor constitutively expressed on naive T cells, highlighting its crucial role in the initial activation of T cells.
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SDS-PAGE
SEC-HPLC
The purity of CD28 Fc Chimera Protein, Human/Cynomolgus/Rhesus macaque is more than 95% determined by SEC-HPLC.
ELISA
Immobilized CD28 Fc Chimera Protein, Human/Cynomolgus/Rhesus macaque (Cat. No. UA011183) at 5.0μg/mL (100μL/well) can bind Biotinylated B7-1 Fc&Avi Tag Protein, Human (Cat. No. UA010460) with EC50 of 0.39-0.49ug/mL.
