2μg (R: reducing conditions, N: non-reducing conditions).
BTLA His Tag Protein, Mouse
BTLA His Tag Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | CD272 |
| Accession | Q32MV9 |
| Amino Acid Sequence | Glu30-Gly176, with C-terminal 10*His |
| Expression System | HEK293 |
| Molecular Weight | 30-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. DDEL RIO ML, KAYE J, RODRIGUEZ BARBOSA JI. Detection of protein on BTLAlow cells and in vivo antibody-mediated down-modulation of BTLA on lymphoid and myeloid cells of C57BL/6 and BALB/c BTLA allelic variants.[J]. Immunobiology: Zeitschrift fur Immunitatsforschung, 2010 ,215(7):570-578. |
Background
B-and T-lymphocyte attenuator (BTLA) is also known as B-and T-lymphocyte-associated protein, CD antigen CD272. BTLA is a inhibitory molecule which belongs to the Ig superfamily that attenuates BCR and TCR-mediated signaling, and thereby functions as a negative regulator of lymphocyte activation. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells.
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SDS-PAGE
ELISA
Immobilized BTLA His Tag Protein, Mouse (Cat. No. UA010627) at 2.0μg/mL (100μL/well) can bind BTLA/CD272 Recombinant Rabbit mAb (S-742-13) (Cat. No. S0B0668) with EC50 of 0.54-0.70 ng/ mL.
