Immobilized Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human (Cat. No. UA010921) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind MICB His Tag Protein, Human(Cat. No. UA010590) with EC50 of 43.01-73.67 ng/ml.
Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human
Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human
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$520 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | NKG2D, CD314, KLRK1, NK cell receptor D |
| Accession | P26718-1 |
| Amino Acid Sequence | Phe78-Val216, with N-terminal Avitag and hIgG1 |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cerwenka, A. et al. (2001) Proc. Natl. Acad. Sci. USA 98:11521. 2.Diefenbach, A. et al. (2001) Nature 413:165. 3.NKG2D and its Ligands (2002) www.rndsystems.com. |
Background
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human ligands for NKG2D include MICA, MICB, and ULBP1,2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity.
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SDS-PAGE
RP-HPLC
ELISA
