1μg (R: reducing condition, N: non-reducing condition).
Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human
Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126 |
| Accession | P08887-1 |
| Amino Acid Sequence | Leu20-Pro365 with Human IgG1 Fc & Avi Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | > 95 % as determined by SDS-PAGE & SEC-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.M Hibi, M Murakami, M Saito, T Hirano, T Taga, TKishimoto. Molecular cloning and expression of an IL-6 signal transducer,gp130.Cell. 1990 Dec 21;63(6):1149-57. |
Background
The interleukin-6 receptor (IL-6R) comprises an 80-kDa IL-6-binding protein (α chain/CD126) and gp130. CD126, a glycoprotein with the ligand-binding site, is part of the human IL-6R, which spans 468 amino acids, including a signal peptide, extracellular region, transmembrane domain, and a short cytoplasmic domain of 19, 339, 28, and 82 amino acids, respectively. IL-6R is present on multiple myeloma, hepatocellular carcinoma, prostate carcinoma, and epidermoid carcinoma cells. The IL-6/IL-6R pathway drives tumor growth, particularly in gliomas, making IL-6R a drug delivery target and a therapeutic target. Primary human cartilage cells express IL-6R, which is upregulated by IL-6, positioning cartilage cells as direct targets of IL-6.
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SDS-PAGE
SEC-HPLC
The purity of Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human is greater than 95% as determined by SEC-HPLC.
ELISA
Immobilized IL-6 Protein, Human (Cat. No. UA040052) at 2.0μg/mL (100μL/well) can bind Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human (Cat. No. UA011222) with EC50 of 8.02-11.36ng/mL.
