2μg (R: reducing condition).
Biotinylated IL-1 alpha/IL-1F1 His&Avi Tag Protein, Mouse
Biotinylated IL-1 alpha/IL-1F1 His&Avi Tag Protein, Mouse
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$516 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | IL1A,IL-1 alpha,IL-1F1,IL1α |
| Accession | P01582 |
| Amino Acid Sequence | Ser 115 - Ser 270 with His &Avi Tag at C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 25-30 kDa(Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS ,pH7.4 ,5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Wrublewsky S, Rother S, Pohlemann F, Radanovic T, Junker F, Boewe AS, Schunk S, Roma LP, Ruiz-Gómez G, Pisabarro MT, MacDonald PE, Menger MD, Laschke MW, Ampofo E. Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets. Sci Adv. 2025 Aug 8;11(32):eady8566. |
Background
Interleukin-1α (IL-1α, aliases IL-1A, IL1, IL1-ALPHA, IL1F1) is a master cytokine of the interleukin-1 family. Constitutively produced by epithelial cells, it is abundant in normal human epidermis—present in equal amounts in living keratinocytes and the stratum corneum—where it underpins the skin barrier against pathogens. Acting via the IL-1 receptor, IL-1α triggers metabolic, hematopoietic, and immune responses both at baseline and rapidly after infection. In vitro, it is active at picomolar–femtomolar levels; in vivo, it initiates immediate immune defense upon microbial challenge.
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SDS-PAGE
SEC-HPLC
The purity of Biotinylated IL-1 alpha/IL-1F1 His&Avi Protein, Mouse is greater than 95% as determined by SEC-HPLC.
