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Biotinylated ICOS/CD278(C136S,C137S) Fc&Avi Tag Protein, Human

Biotinylated ICOS/CD278(C136S,C137S) Fc&Avi Tag Protein, Human

Catalog Number: UA011306 Brand: UA BIOSCIENCE
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$562.00 SGD
$562.00 SGD
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Product Details

Product Specification


Species Human
Synonyms ICOS,CD278,AILIM,Inducible T-cell costimulator
Accession Q9Y6W8-1
Amino Acid Sequence

Glu21-Phe141（C136S,C137S）with Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight 50-60kDa (Reducing)
Purity ＞95% by SDS-PAGE&>80% SEC-HPLC
Conjugation Biotin
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Vetter VK, Benoit T, Rahmani-Khajouei S, Bender D, Inauen R, Djerbi N, Zenz T, Bühler MM. Nodal gamma-delta T-cell lymphoma: expression of TFH-markers causing diagnostic difficulties in a newly described entity. Virchows Arch. 2025 Sep 26.
2.Pascual-García S, Cobo R, Bolinches JL, Ortiz I, Viamonte P, Sempere-Ortells JM, Martínez-Peinado P. Advanced Immunomodulation in Rheumatoid Arthritis: Immune Checkpoints, microRNAs, and Cell-Based Therapies. Biomedicines. 2025 Sep 7;13(9):2186.

Background

ICOS, a CD28 family receptor also designated as AILIM/CD278, functions as a crucial immunoregulator. It potently augments T-cell responses against foreign antigens through promoting proliferation, lymphokine secretion, and enhanced cell-cell interactions while facilitating B-cell antibody production. Although not affecting IL-2, ICOS induces IL-10 synthesis and sustains T-cell viability by preventing apoptosis in pre-activated T-cells. Its pivotal role in CD40-mediated immunoglobulin class switching underscores its importance in humoral immunity. Structurally, ICOS forms functionally active homodimers stabilized by disulfide bonds. Collectively, these properties establish ICOS as a master regulator coordinating T-cell activation, B-cell help, and antibody diversification in adaptive immunity.

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SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of Biotinylated ICOS/CD278(C136S,C137S) Fc&Avi Tag Protein, Human is more than 80% determined by SEC-HPLC.

ELISA

Immobilized B7-H2/ICOSLG His Tag Protein, Human (Cat. No. UA010058) at 5.0μg/mL (100μL/well) can bind Biotinylated ICOS/CD278(C136S,C137S) Fc&Avi Tag Protein, Human (Cat. No. UA011306) with EC50 of 0.95-1.31 ng/mL.