Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 5ng/ml.
PDGF-BB Protein, Rat
PDGF-BB Protein, Rat
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; |
| Accession | Q05028 |
| Amino Acid Sequence | Ser74-Thr182 |
| Expression System | Yeast |
| Molecular Weight | 15-17 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 4mM HAc |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in 10mM HAc after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Genes Dev. 2008 May 15;22(10):1276-312. |
Background
Platelet-derived growth factor-BB (PDGF-BB) is a homodimeric isoform of the PDGF family of growth factors that plays a crucial role in regulating cell proliferation, migration, and survival. In rats, PDGF-BB is produced by various cell types, including platelets, endothelial cells, and smooth muscle cells, and acts on cells expressing PDGF receptors, such as PDGFR-α and PDGFR-β. Upon binding to its receptors, PDGF-BB activates intracellular signaling pathways, such as the Ras-MAPK and PI3K-Akt pathways, leading to cellular responses involved in tissue repair, angiogenesis, and fibrosis. PDGF-BB is known for its mitogenic and chemotactic effects on mesenchymal cells, including fibroblasts and smooth muscle cells, and plays a critical role in wound healing, tissue remodeling, and vascular development.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
