2μg (R: reducing condition, N: non-reducing condition).
IL-17A Protein, Rat
IL-17A Protein, Rat
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$236 USD
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8) |
| Accession | Q61453 |
| Amino Acid Sequence | Ala18-Ser150 |
| Expression System | HEK293 |
| Molecular Weight | 12-22kDa (Reducing) |
| Purity | >95% by SDS-PAGE; >90% by HPLC; |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Int Immunopharmacol. 2023 Oct:123:110757. |
Background
Interleukin 17A (IL-17A) is a major member of the IL-17 cytokine family and is produced mainly by T helper 17 (Th17) cells. In healthy individuals, IL-17A has a host-protective capacity, but excessive elevation of IL-17A is associated with the development of autoimmune diseases and cancer. IL-17A is essential for modulating the interplay between commensal microbes and epithelial cells at our borders (i.e., skin and mucosae), and yet, for protecting us from microbial invaders, thus preserving mucosal and skin integrity.
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SDS-PAGE
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Immobilized IL-17A Protein, Rat (Cat. No. UA040474) at 2.0μg/mL (100μL/well) can bind Human IL-17 RA / CD217 Protein, Fc Tag with EC50 of 9.02-10.88ng/ml.
