2μg (R: reducing condition, N: non-reducing condition).
IL-17A Protein, Human
IL-17A Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8); |
| Accession | Q16552 |
| Amino Acid Sequence | Gly24-Ala155 |
| Expression System | HEK293 |
| Molecular Weight | 16-20 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cytokine. 2021 Mar:139:154344. |
Background
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Human Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The six known members of this family are secreted as homodimers. Human IL-17 exhibits 63% amino acid identity with mouse IL-17，IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.0kDa, disulfide-linked homodimer of two 132 amino acid polypeptide chains.
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SDS-PAGE
SEC-HPLC
>95% as determined by SEC-HPLC.
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Immobilized IL-17A Protein, Human (Cat. No. UA040483) at 5.0μg/mL (100μL/well) can bind Human IL-17 RA / CD217 Protein, Fc Tag with EC50 of 1.99-2.45ng/mL.
