Measured in a cell proliferation assay using Balb/c-3T3 mouse embryonic fibroblast cells. The EC50 this effect is less than 10ng/ml in the presence of 10μg/ml heparin.
FGF-17 Protein, Mouse
FGF-17 Protein, Mouse
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$200 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | fgf17b; zgc:101759 |
| Accession | P63075 |
| Amino Acid Sequence | Thr23-Thr216 |
| Expression System | E.coli |
| Molecular Weight | 25kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. K Scearce-Levie and E D Roberson (2008) Genes Brain Behav. 7(3):344-54. |
Background
Fibroblast Growth Factors (FGFs) are polypeptides with diverse activities in development and physiology. The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. Recent evidence suggests that Fgf17 is important in neural patterning. During embryonic development, Fgf17 is expressed in the patterning centers for the rostral forebrain and the midbrain/hindbrain. Studies of Fgf17-deficient mice showed that Fgf17 is required for development of the cerebellar vermis and inferior colliculus and for the regionalization of frontal cortex. Fgf17 ablation reduced the size of the dorsal frontal cortex and the extent of frontal cortex projections to subcortical targets.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
