WB result of PSEN2 Recombinant Rabbit mAb
Primary antibody: PSEN2 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: SH-SY5Y whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 50 kDa
Observed MW: 21 kDa
PSEN2 Recombinant Rabbit mAb (S-2084-14)
PSEN2 Recombinant Rabbit mAb (S-2084-14)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | PSEN2 |
| Synonyms | Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2; AD4; PS2; PSNL2; STM2 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P49810 |
| Clone Number | S-2084-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | SH-SY5Y, HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
PSEN2, which stands for presenilin 2, is a protein encoded by the PSEN2 gene. It is an integral membrane protein that is a key component of the gamma-secretase enzyme complex. This complex is involved in the cleavage of amyloid precursor protein (APP), which generates amyloid-beta peptides. Mutations in the PSEN2 gene have been linked to early-onset familial Alzheimer's disease, as these mutations can lead to an increased production of amyloid-beta 42, a peptide that is more prone to aggregate and form plaques in the brain. PSEN2 is primarily located in the endoplasmic reticulum and Golgi apparatus, and it plays a crucial role in regulating cellular processes such as protein trafficking and signal transduction.
Picture
Picture
Western Blot
Immunohistochemistry
IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human endometrial cancer. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung adenocarcinoma. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
