Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell)labelling Human CD8 antibody at 1/2000 (0.1 μg)dilution (Right) compared with a Mouse lgG1 isotype control (Left).Then cells were stained with CD4 - Alexa Fluor® 647 separately. Gated on total viable cells.
Mouse anti-Human CD8 Antibody (S-R533)
Mouse anti-Human CD8 Antibody (S-R533)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD8 |
| Synonyms | T-lymphocyte differentiation antigen T8/Leu-2; T-cell surface glycoprotein CD8 alpha chain; MAL; CD8a |
| Location | Cell membrane |
| Accession | P01732 |
| Clone Number | S-R533 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD8A encodes the CD8 alpha chain of the αβT cells, proposed as a quantifiable indicator for CD8+ CTL recruitment or activity assessments and a robust biomarker for responses to anti-PD-1/PD-L1 therapy. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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