Flow cytometric analysis of human peripheral blood labelling Human CD41a antibody at 1/2000 (0.1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD42b - Alexa Fluor® 488 separately. Gated on total viable cells.
Mouse Anti-Human CD41a Antibody (S-R554)
Mouse Anti-Human CD41a Antibody (S-R554)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD41a |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; ITGA2B; GP2B; ITGAB |
| Location | Membrane |
| Accession | P08514 |
| Clone Number | S-R554 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD41, also known as Integrin α-IIb or GPαIIb, is a protein expressed on platelets and megakaryocytes. CD41 is a component of the platelet membrane glycoprotein complex and non-covalently associates with CD61 (Integrin β-3) to form the αIIbβ3 complex, which is an essential integrin in platelets. It plays a crucial role in platelet activation and aggregation, particularly during thrombus formation and hemostasis. In clinical practice, the detection of CD41 is essential for diagnosing and studying platelet-related diseases. For instance, immunostaining for CD41 can help identify micromegakaryocytes, which might be confused with primitive megakaryocytes or lymphocytes in Wright-Giemsa staining, leading to missed diagnoses. CD41 staining can significantly improve the detection rate of micromegakaryocytes, which is crucial for the diagnosis and therapeutic monitoring of certain hematological disorders.
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