Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Human CD303 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD123 - PE/Cy7 Antibody separately.
Mouse Anti-Human CD303 Antibody (S-R662)
Mouse Anti-Human CD303 Antibody (S-R662)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD303 |
| Synonyms | C-type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C |
| Location | Cell membrane |
| Accession | Q8WTT0 |
| Clone Number | S-R662 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD303, also known as BDCA-2 or CLEC4C, is a 38 kD type II transmembrane glycoprotein and a member of the C-type lectin superfamily. It is specifically expressed on plasmacytoid dendritic cells (pDCs) and plays a crucial role in antigen capture and processing, as well as in cell adhesion and signaling. CD303 is involved in the presentation of antigens to T cells and can mediate the inhibition of IFN-α/β expression in pDCs when cross-linked. This molecule is also a potential therapeutic target in diseases such as systemic lupus erythematosus due to its role in immune regulation.
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