Flow cytometric analysis of human peripheral blood lymphocytes labelling Human CD197 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Cells were stained with CD3 - Brilliant Violet 421™ Antibody separately.
Mouse Anti-Human CD197 Antibody (S-R704)
Mouse Anti-Human CD197 Antibody (S-R704)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD197 |
| Synonyms | C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; CMKBR7; EBI1; EVI1; CCR7 |
| Location | Cell membrane |
| Accession | P32248 |
| Clone Number | S-R704 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood lymphocytes |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD197, also known as CCR7, is a seven-transmembrane, G-protein-coupled receptor that plays a crucial role in the immune system. It is expressed on activated T cells, B cells, and dendritic cells, and is involved in lymphocyte migration to lymph nodes and the maturation of dendritic cells. CD197 binds to chemokines such as CCL19 and CCL21, which are essential for the interaction between T cells and dendritic cells, thereby linking innate and adaptive immunity. Additionally, its expression is significantly upregulated in B cells infected by the Epstein-Barr virus.
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