1μg (R: reducing condition, N: non-reducing condition).
MICA His Tag Protein, Human
MICA His Tag Protein, Human
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$256.00 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | FLJ60820; MGC111087; PERB11.1 |
| Accession | Q29983 |
| Amino Acid Sequence | Glu24-Gln308, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Journal List J Immunother Cancer v.7; 2019 . |
Background
MICA, a 383-amino-acid protein, interacts with the NKG2D receptor and the T cell receptor (TCR) to stimulate the activation of natural killer (NK) cells, αβ CD8 T cells, and γδ T cells. Typically undetectable in most cells, MICA is frequently found in epithelial tumors and its expression can be triggered by both bacterial and viral infections. The interaction between MICA and NKG2D leads to the activation of cytolytic functions and cytokine production in these effector cells, playing a crucial role in tumor surveillance, defense against viral infections, and the modulation of autoimmune responses.
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SDS-PAGE
SEC-HPLC
The purity of MICA His Tag Protein, Human is greater than 95% as determined by SEC-HPLC
ELISA
Immobilized NKG2D/CD314 Fc Chimera Protein, Human (Cat. No. UA010732) at 2.0μg/mL (100μL/well) can bind MICA His Tag Protein, Human (Cat. No. UA011069) with EC50 of 0.093-0.15μg/mL.
