1μg (R: reducing condition, N: non-reducing condition).
LDLR His Tag Protein, Cynomolgus
LDLR His Tag Protein, Cynomolgus
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | FH, FHC, LDLCQ2 |
| Accession | XP_005588053.2 |
| Amino Acid Sequence | Ala22-Gly788 with His tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 120-140kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Canbay E, Canda E, Yazıcı H, Kasıkcı GK, Durmaz B, Copur O, Tahhan B, Düzgün D, Koru ZE, Sezer E, Aydın D, Levent RE, Ucar SK, Coker M, Sozmen EY. Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia. Lipids Health Dis. 2024 Nov 13;23(1):374. |
Background
The Low-Density Lipoprotein (LDL) Receptor, also known as LDLR, FH, FHC, or LDLCQ2, is a mosaic protein composed of approximately 840 amino acids (after signal peptide removal) that mediates the endocytosis of cholesterol-rich LDL. This cell-surface receptor recognizes apolipoprotein B100, which is embedded in the phospholipid outer layer of LDL particles, as well as apolipoprotein E found in chylomicron remnants and VLDL remnants (IDL). The LDL receptor belongs to the LDL receptor gene family.
LDL receptor complexes are located in clathrin-coated pits on the cell surface. When bound to LDL-cholesterol via adaptors, these complexes are internalized to form clathrin-coated vesicles within the cell. This process, known as endocytosis, allows for the efficient internalization of LDL-cholesterol and prevents it from diffusing across the membrane surface. This occurs in all nucleated cells, but is most prominent in the liver, which removes approximately 70% of LDL from the circulation.
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SDS-PAGE
SEC-HPLC
The purity of LDLR His Tag Protein, Cynomolgus is more than 95% determined by SEC-HPLC.
