WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
Lysate: HeLa whole cell lysate 20 µg
Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
Predicted MW: 68 kDa
Observed MW: 68 kDa
Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-307-108)
Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-307-108)
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$120.00 USD
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Lamin B1 |
| Synonyms | Lamin-B1, LMN2, LMNB, LMNB1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus lamina |
| Accession | P20700 |
| Clone Number | SDT-307-108 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | HRP |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:5000-1:50000 | null |
Background
Lamin B1 is a critical component of the nuclear lamina, a protein network underlying the inner nuclear membrane, and plays essential roles in nuclear organization, chromatin regulation, and cell proliferation. It is particularly important during brain development, where it contributes to neuronal migration and the maintenance of nuclear integrity. Lamin B1 also interacts with chromatin and the nuclear pore complex, influencing gene expression and DNA replication. The balance of Lamin B1 is crucial; both its overexpression and deficiency can lead to developmental abnormalities and neurodegenerative diseases. Recent studies have highlighted its dynamic association with euchromatin regions, suggesting a role in gene regulation and the cellular response to stimuli such as epithelial-to-mesenchymal transition (EMT). Lamin B1's interaction with the genome is complex and involves the formation of lamina-associated domains (LADs), which can change during cellular transformations, indicating its active participation in chromatin remodeling and the regulation of cellular identity.
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Western Blot
WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
Lysate: mouse spleen lysate 20 µg
Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
Predicted MW: 68 kDa
Observed MW: 68 kDa
WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
Lysate: rat heart lysate 10 µg
Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
Predicted MW: 68 kDa
Observed MW: 68 kDa
