KGF/FGF-7 Protein, Human
KGF/FGF-7 Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Antigen | KGF/FGF-7 |
| Synonyms | FGF-7, Fibroblast growth factor 7, HBGF-7, Keratinocyte growth factor, KGF |
| Accession | P21781 |
| Amino Acid Sequence | Cys32-Thr194 |
| Expression System | E.coli |
| Molecular Weight | 17kDa (Reducing) |
| Purity | >95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Fibroblast growth factor (FGF-7), a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. As a well-characterized paracrine growth factor for tissue growth and regeneration, fibroblast growth factor 7 (FGF-7) is involved in a number of physiological and pathological processes, including lung disease and cancer. The stromal-derived FGFs, such as FGF-7 and FGF-10, control epithelial cell resident FGFR2IIIb activities, promote net tissue homeostasis, and restraint tumor cells from progression to malignancy.
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Bioactivity
Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells，The EC50 for this effect is less than 3ng/ml.
SDS-PAGE
RP-HPLC
SPR
Anti-His antibody Immobilized on CM5 Chip captured FGF-R2 (IIIb) His Tag, Human (Cat. No. UA010145), can bind KGF/FGF-7(Cat. No. UA040040), Human with an affinity constant of 0.19μM as determined in SPR assay.
