Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The EC50 for this effect is less than 5ng/ml.
IL-8 (28-99) Protein, Human
IL-8 (28-99) Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-8, IL8, CXCL8, NAP-1, NAF |
| Accession | P10145 |
| Amino Acid Sequence | Ser28-Ser99 |
| Expression System | HEK293 |
| Molecular Weight | 9kDa (Reducing) |
| Purity | ＞95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Van Damme J, Rampart M, Conings R, et al. 1990. Eur J Immunol. 20:2113-8.1/2. 2.McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120 |
Background
IL-8(Interleukin-8) is one of the first discovered chemokines and belongs to the CXCL family, in which the first two conserved cysteines are separated by one residue. In vivo, IL-8 exists in two forms: a 77-amino acid protein produced by endothelial cells, and the more active 72- amino acid protein produced by monocytes. IL-8 is often associated with inflammation, it has been cited as a proinflammatory mediator in gingivitis and psoriasis. The functions of IL-8 are to induce rapid changes in cell morphology, activate integrins, and release the granule contents of neutrophils. Thus, IL-8 can enhance the antimicrobial actions of defense cells. It is secreted by monocytes, macrophages and endothelial cells. IL-8 signals through CXCR1 and CXCR2 to chemoattract neutrophils, basophils, and T cells. IL-8 is also a potent promoter of angiogenesis.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
SEC-HPLC
