Measured by cytotoxicity assay using TF-1 cells. The EC50 for this effect is less than 20ng/ml.
IL-6 Protein, Canine
IL-6 Protein, Canine
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$356.00 USD
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Product Details
Product Details
Product Specification
| Species | Canine |
| Synonyms | Interleukin-6, IL-6;Interleukin-6, IL-6, B-Cell Hybridoma Growth Factor, Interleukin HP-1, Il6, Il-6； |
| Accession | P41323 |
| Amino Acid Sequence | Phe21-Met207 |
| Expression System | E.coli |
| Molecular Weight | 24kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris,80mM NaCl,pH8.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Ferguson-Smith AC, Chen YF, Newman MS, et al. 1988. Genomics. 2:203-8. 2.van der Poll T, Keogh CV, Guirao X, et al. 1997. J Infect Dis. 176:439-44. 3.Ming JE, Cernetti C, Steinman RM, et al. 1989. J Mol Cell Immunol. 4:203-11; discussion 211-2. 4.Bastard JP, Jardel C, Delattre J, et al. 1999. Circulation. 99:2221-2. 5.Heinrich PC, Behrmann I, Muller-Newen G, et al. 1998. Biochem J. 334 ( Pt 2):297-314. 6.Van Snick J, Cayphas S, Szikora JP, et al. 1988. Eur J Immunol. 18:193-7. |
Background
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that also has an important role in immunity. Mouse IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 in regulating the acute phase response. Mouse IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 has a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, nerve cells differentiation in hepatocytes, and acute phase reactants.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
