1μg (R: reducing condition, N: non-reducing condition).
IL-18Rβ/IL-1R7 His Tag Protein, Human
IL-18Rβ/IL-1R7 His Tag Protein, Human
Price:
Regular price
$144.00 USD
Regular price
Sale price
$144.00 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD218a;CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra |
| Accession | O95256 |
| Amino Acid Sequence | Phe20-Arg356, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 53-63kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE&SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Parnet, P. et al. (1996) J. Biol. Chem. 271:3967. |
Background
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either. independently of SLC12A3, or as a complex with SLC12A3.
Picture
Picture
SDS-PAGE
SEC-HPLC
HPLC＞95%
ELISA
Measured by its binding ability in a functional ELISA. When IL-18Rβ/IL-1R7 His Tag, Human (Cat. No. UA010888) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 Fc Chimera, Human (Cat. No. UA010874) binds with an ED50 of 8.62-11.50 ng/mL.
