1μg (R: reducing condition, N: non-reducing condition).
IL-18Rβ/IL-1R7 Fc Chimera Protein, Human
IL-18Rβ/IL-1R7 Fc Chimera Protein, Human
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$160.00 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b antigen; CD218b; CDw218b; IL-1 R7; IL-18 R beta; IL-18 receptor accessory protein; IL-18 receptor beta; IL18R beta; IL-18RAcP; IL18RAP; IL18RB; IL-18Rb; IL-18Rbeta; IL-18R-beta; IL-1R accessory protein-like; IL1R7; IL-1R7; IL-1R-7; IL-1RAcPL; interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; MGC120589; MGC120590 |
| Accession | O95256 |
| Amino Acid Sequence | Phe20-Arg356 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4,5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967. |
Background
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex consists of two subunits: IL-18Rα (also known as IL-1R5 or IL-1Rrp) and IL-18Rβ (also known as IL-1R7 or AcPL). Both subunits belong to the IL-1 receptor superfamily. IL-18R is widely expressed in various tissues, including the spleen, thymus, leukocytes, liver, lung, heart, small and large intestines, prostate, and placenta.
The IL-18 receptor complex is responsible for binding the pro-inflammatory cytokine IL-18, but not IL-1α or IL-1β. It is involved in IL-18-mediated IFNγ synthesis from T-helper 1 (Th1) cells and contributes to IL-18-induced cytokine production, either independently of SLC12A3 or as a complex with SLC12A3.
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SDS-PAGE
SEC-HPLC
96.3%
ELISA
When IL-18Rβ/IL-1R7 Fc Chimera Protein, Human (Cat. No. UA010873) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 His Tag Protein, Human (Cat. No. UA010914) binds with an ED50 of 40.10-49.63ng/mL.
