Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is less than 30ng/ml.
IL-17F Protein, Human
IL-17F Protein, Human
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$152.00 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-17F; IL-17F; Cytokine ML-1 |
| Accession | Q96PD4 |
| Amino Acid Sequence | Arg31-Gln163 |
| Expression System | E.coli |
| Molecular Weight | 17 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Cytokine. 2009 Apr;46(1):7-11. Epub 2009 Feb 23. |
Background
Interleukin-17F (IL-17F) is a member of the interleukin-17 cytokine family that plays a key role in regulating inflammatory responses and immune reactions. IL-17F is primarily produced by activated T cells, particularly Th17 cells, and acts on various cell types, including epithelial cells, fibroblasts, and immune cells. IL-17F is involved in the pathogenesis of inflammatory and autoimmune diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. It promotes the production of pro-inflammatory cytokines and chemokines, leading to recruitment of immune cells to sites of inflammation and tissue damage.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Immobilized IL-17F Protein, Human (Cat. No. UA040308) at 5μg/mL (100μL/well) can bind IL-17 RA Protein, Human (Cat. No. UA040024) with EC50 of 0.73-0.88 μg/mL.
