Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The EC50 for this effect is less than 10ng/ml.
IL-12/IL-23 p40 Monomer Protein, Human
IL-12/IL-23 p40 Monomer Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40); IL-12 subunit p40; NK cell stimulatory factor chain 2 (NKSF2); |
| Accession | P29460 |
| Amino Acid Sequence | Ile23-Ser328 |
| Expression System | CHO |
| Molecular Weight | 40 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Nat Med. 2015 Jul;21(7):719-29. Epub 2015 Jun 29. |
Background
The IL-12/IL-23 p40 monomer is a subunit shared between the interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokines. It is a critical component of both the IL-12 and IL-23 heterodimers, which are proinflammatory cytokines that play essential roles in regulating immune responses. The IL-12/IL-23 p40 monomer is involved in the formation of the biologically active IL-12 and IL-23 heterodimers, which bind to their respective receptors and activate signaling pathways that modulate immune cell function. Notably, the p40 subunit itself has been shown to exhibit biological activity independent of its role in forming the heterodimers, including the ability to act as an antagonist for IL-12 and IL-23 signaling by competing for receptor binding.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
SEC-HPLC
>95% as determined by SEC-HPLC.
