CM5 Chip captured RSPO3 Protein, Human (Cat. No. UA040025), can bind ZNRF3 His Tag Protein, Human (Cat. No. UA011107) with an affinity constant of 0.42μM as determined in SPR assay.
ZNRF3 His Tag Protein, Human
ZNRF3 His Tag Protein, Human
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$36.00 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | ZNRF3, Zinc,RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203 |
| Accession | Q9ULT6-1 |
| Amino Acid Sequence | Lys56-Met219 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 22-23kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Fu S, Qian M, Yuan Z, Su S, Ma F, Li F, Xu Z. A new perspective on selenium's impact on renal function: European population-based analysis of plasma proteome-mediated Mendelian randomization study. Front Endocrinol (Lausanne). 2024 Sep 12;15:1410463. |
Background
The transmembrane E3 ubiquitin ligase, Zinc and Ring Finger 3 (ZNRF3), serves as a negative feedback regulator of Wnt signaling. ZNRF3 is associated with the Wnt receptor complex and inhibits Wnt signaling by promoting the turnover of Frizzled and LRP6. Additionally, ZNRF3 functions as a tumor suppressor in the intestinal stem cell compartment by inhibiting the Wnt signaling pathway.
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SDS-PAGE
SEC-HPLC
SPR
