1μg (R: reducing condition, N: non-reducing condition).
VSIG4 His Tag Protein, Cynomolgus
VSIG4 His Tag Protein, Cynomolgus
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$220 USD
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | VSIG4, CRIg, Z39IG |
| Accession | XP_005593850.1 |
| Amino Acid Sequence | Arg25-Pro288, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & ＞95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Pan W, Huang W, Zheng J, Meng Z, Pan X. Construction of a prognosis model of head and neck squamous cell carcinoma pyroptosis and an analysis of immuno-phenotyping based on bioinformatics. Transl Cancer Res. 2024 Jan 31;13(1):299-316. |
Background
VSIG4 (V-set and immunoglobulin domain containing 4), also known as CRIg and Z39IG, is a type I transmembrane protein of the B7 family within the Ig superfamily. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.
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SDS-PAGE
SEC-HPLC
The purity of VSIG4 His Tag Protein, Cynomolgus is more than 95% determined by SEC-HPLC.
ELISA
Immobilized human iC3b at 5.0μg/mL (100μL/well) can bind VSIG4 His Tag, Cynomolgus (Cat. No. UUA010980)with EC50 of 0.71-1.11 μg/ mL.
