Rat IFN-γ Recombinant Rabbit mAb (S-3603)
Rat IFN-γ Recombinant Rabbit mAb (S-3603)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IFN-γ |
| Clone Number | S-3603 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Rt |
Background
Rat IFN-γ (interferon-gamma) is a 15–16 kDa, 136-amino-acid type II cytokine secreted chiefly by activated NK cells and Th1-type CD4⁺ T cells. It signals through a high-affinity heterodimeric receptor composed of IFN-γR1/IFN-γR2, activating the JAK–STAT1 pathway to up-regulate MHC class I and II molecules, chemokines such as CXCL9/10, and multiple antimicrobial effectors. In rats this molecule is encoded by the Ifng gene on chromosome 7 and is heavily N-glycosylated; it functions as a non-covalent antiparallel dimer with species-specific biological activity that is essential for macrophage activation, Th1 polarization, and control of intracellular pathogens.
