Bcl-xL His Tag Protein, Human

Catalog Number: UA011023 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE

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$190 USD

Size: 10μg 50μg 500μg

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Product Details

Product Specification

Species	Human
Synonyms	Bcl-2-Like Protein 1; Bcl2-L-1; Apoptosis Regulator Bcl-X; BCL2L1; BCL2L; BCLX
Accession	Q07817
Amino Acid Sequence	Met1-Arg212
Expression System	E.coli
Molecular Weight	24.85 KDa
Purity	>95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Liquid
Storage Buffer	20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.
Stability & Storage	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Background

Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

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Bcl-xL His Tag Protein, Human