Flow cytometric analysis of C57BL/6 mouse thymocytes labelling CD95 antibody at 1/200 dilution (1 μg) / (Red) compared with a Armenian hamster IgG (Black) Isotype control followed by Anti-Armenian Hamster IgG (H+L) biotin separately. Then cells were stained with Sav-PE antibody.
Armenian hamster Anti-Mouse CD95 Antibody (S-R535)
Armenian hamster Anti-Mouse CD95 Antibody (S-R535)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | CD95 |
| Synonyms | Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; Apt1; Tnfrsf6; Fas |
| Location | Cell membrane |
| Accession | P25446 |
| Clone Number | S-R535 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD95, also known as Fas or APO-1, is a 48 kDa type-I transmembrane receptor of the TNF-receptor superfamily that, upon trimerization by its cognate ligand CD95L (FasL), assembles the death-inducing signaling complex (DISC) by recruiting the adaptor FADD and procaspase-8/10, triggering a caspase cascade that culminates in apoptosis, thereby governing immune homeostasis, peripheral tolerance, and elimination of infected or oncogenic cells, while dysregulation of this pathway contributes to autoimmune lymphoproliferative syndrome, cancer immune evasion, and resistance to chemotherapy.
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