Alexa Fluor® 488 Rat Anti-Mouse CD140a Antibody (S-R682)
Alexa Fluor® 488 Rat Anti-Mouse CD140a Antibody (S-R682)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD140a |
| Synonyms | Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; Platelet-derived growth factor alpha receptor; Pdgfra |
| Location | Cell membrane |
| Accession | P26618 |
| Clone Number | S-R682 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD140a, also known as Platelet-Derived Growth Factor Receptor Alpha (PDGFRα), is a cell surface receptor tyrosine kinase that plays a crucial role in various biological processes. It is a member of the receptor tyrosine kinase (RTK) III class and is widely expressed in cells of mesenchymal origin, including fibroblasts, endothelial cells, glial cells, and certain tumor cells. CD140a binds to various isoforms of platelet-derived growth factors (PDGFs) such as PDGF-AA, PDGF-AB, and PDGF-BB, forming homodimers or heterodimers with CD140b (PDGFRβ) to mediate cellular responses. This receptor is involved in cell proliferation, differentiation, migration, and survival, and is essential for embryonic development, wound healing, and the regulation of platelet activation.
