Measured by its ability to inhibition on MPC-11 cell proliferation. The EC50 for this effect is less than 40ng/ml.
Activin A Protein, Human/Mouse/Rat
Activin A Protein, Human/Mouse/Rat
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Regular price
$200.00 USD
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$200.00 USD
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Product Details
Product Details
Product Specification
| Species | Human, Mouse, Rat |
| Synonyms | Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein (EDF); |
| Accession | P08476 |
| Amino Acid Sequence | Gly311-Ser426 |
| Expression System | E.coli |
| Molecular Weight | 14 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 4mM HCl |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16239-44. Epub 2007 Oct 2. |
Background
Activin A is a dimeric glycoprotein belonging to the transforming growth factor-beta (TGF-β) superfamily of cytokines. It is involved in various biological processes, including embryonic development, reproductive function, and regulation of the immune system. Activin A is produced by a wide range of cell types, including immune cells, endothelial cells, and reproductive tissues. It exerts its effects by binding to the activin type II receptors, leading to the activation of downstream signaling pathways involved in cell proliferation, differentiation, and immune modulation. Activin A has been implicated in the regulation of inflammation, tissue repair, and the pathogenesis of various diseases, including cancer and autoimmune disorders.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Immobilized Activin A Protein, Human (Cat. No. UA040343) at 1.0μg/mL (100μL/well) can bind ACVR2B Fc Chimera, Human (Cat. No. UA010213) with EC50 of 9.27-13.85 ng/mL.
Immobilized Activin A Protein, Human/Mouse/Rat (Cat. No. UA040343) at 1.0μg/mL (100μL/well) can bind ACVR2A Fc Chimera Protein, Human (Cat. No. UA010196) with EC50 of 1.33-2.08ng/mL.
