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InVivo recombinant Flt-3L Protein, Mouse

InVivo recombinant Flt-3L Protein, Mouse

Catalog Number: UA040505 Brand: UA BIOSCIENCE
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$584 USD
$584 USD
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Product Details

Product Specification


Synonyms FL; FLG3L; Flt3 ligand; Flt-3 Ligand; Flt3L; FLT3LG; fms-related tyrosine kinase 3 ligand; SL cytokine,FLT3L
Accession P49772
Amino Acid Sequence

Gly27-Arg188, with C-terminal His Tag

Expression System HEK293
Molecular Weight

20-33kDa(Reducing)

Purity

>95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4.

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles

Background

FLT-3 ligand promotes long- term expansion and differentiation of human pro-B-cells in the presence of IL-7 or in combination of IL-7 and IL-3.The human FLT-3 ligand also stimulates the proliferation of cells expressing murine FLT-3 receptors. In combination with SCF and IL-3, FLT-3 ligand can cause expansion of cells with the marker spectrum CD34(+) CD38(-). Alone, FLT-3 ligand supports the survival of precursors in the lineage of blood-forming cells such as CFU-GM, CFU- GEMM, and the very primitive high proliferative potential colony-forming cells, HPP- CFC. flt-3 ligand only has marginal effects on progenitors for erythroid cells and megakaryocytes.

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Bioactivity

Determined by the dose-dependent stimulation of the proliferation of human OCI-AML5 cells.The EC50 for this effect is less than 3ng/ml.

SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).