Measured in a cell proliferation assay using CTLL-2 Mouse cytotoxic T cells. The EC50 for this effect is < 5 ng/mL.
IL-15 Protein, Mouse
IL-15 Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-15, IL-15 |
| Accession | P48346 |
| Amino Acid Sequence | Asn49-Ser162 |
| Expression System | E.coli |
| Molecular Weight | 17-30 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer |
PBS, pH 7.4
|
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Exp Ther Med. 2021 Jul;22(1):675. |
Background
Interleukin-15 (IL-15) supports the homeostasis of cytotoxic immune cells, exhibits a broad biological activity. IL-15 stimulate the proliferation of activated T cells as well as to facilitate the induction of cytotoxic T-lymphocytes (like CD8+), and the generation, proliferation, and activation of NK cells. Therefore, IL-15 is applied to the rapidly expanding cancer immunotherapy field combining with other agents, i.e., checkpoint inhibitors, monoclonal antibodies, chemotherapy, radiation, and chimeric antigen receptor T (CAR-T) cells, in order to target multiple mechanisms and enhance the immune response against tumors, which provides advantages to control and treat cancers.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
