Measured in a cell proliferation assay using TF-1 human erythroleukemic cells, the EC50 for this effect is less than 2ng/ml.
IL-13 Protein, Rat
IL-13 Protein, Rat
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | Interleukin-13, IL-13, T-cell activation protein P600 |
| Accession | P42203 |
| Amino Acid Sequence | Thr19-His131 |
| Expression System | HEK293 |
| Molecular Weight | 20-27 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 1993 Mar 18;362(6417):248-50. |
Background
Rat IL-13 is a 12.3 kDa, non-glycosylated monomeric cytokine consisting of 113 amino acids (Uniprot ID: P42203) with a bundled four α-helix configuration stabilized by two internal disulfide bonds. The mature protein shares 75% amino acid sequence identity with mouse IL-13, 59% with human, and 60% with rhesus monkey orthologs, reflecting strong functional conservation across species.
IL-13 is primarily secreted by T helper type 2 (Th2) cells but is also produced by various immune and non-immune cell types including mast cells, eosinophils, basophils, NK cells, and epithelial cell. In rats, IL-13 expression is dynamically regulated during immune challenges, with elevated levels detected in bronchoalveolar lavage (BAL) cells following allergen stimulation.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
SEC-HPLC
>95% as determined by SEC-HPLC.
