Phospho-TDP43 (Ser409/410) Recombinant Rabbit mAb

Phospho-TDP43 (Ser409/410) refers to the form of TAR DNA-binding protein 43 (TDP-43) that has been specifically phosphorylated at serine residues 409 and 410 in its C-terminal region. This aberrant hyperphosphorylation is a hallmark biochemical feature of pathological TDP-43 protein. Under normal conditions, TDP-43 is predominantly localized in the nucleus, where it participates in RNA splicing, transport, and stability regulation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), TDP-43 mislocalizes from the nucleus to the cytoplasm and aggregates to form insoluble, hyperphosphorylated inclusions, with phosphorylation at Ser409/410 being a core feature of these pathological inclusions. This phosphorylation modification is considered to be closely associated with disease progression—it not only serves as a "molecular fingerprint" of pathological conformational changes in TDP-43 but may also promote its aggregation, exacerbate cytotoxicity, and interfere with the autophagy-lysosomal clearance pathway. Consequently, antibodies specifically targeting p-TDP-43 (Ser409/410) have been widely used in pathological diagnosis and histological subtyping of neurodegenerative diseases, as well as serving as biomarkers for evaluating therapies targeting TDP-43 pathology.