1μg (R: reducing condition).
TLR2 Flag-His Tag Protein, Human(SP17)(Detergent)
TLR2 Flag-His Tag Protein, Human(SP17)(Detergent)
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | toll-like receptor 2 |
| Accession | O60603 |
| Concentration | 0.13mg/ml by Nanodrop |
| Amino Acid Sequence | O60603, https://www.uniprot.org/uniprotkb/O60603/entry |
| Expression System | HEK293 |
| Molecular Weight | 90 kDa |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid with detergent |
| Storage Buffer | 50 mM Hepes, ph8.0, 500 mM NaCl, 0.05%DDM, 0.01%CHS. |
| Stability & Storage | ·6 months from date of receipt, -60 to -80 °C as supplied. |
| Reference | 1. Jin M S, Kim S E, Heo J Y, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide[J]. Cell, 2007, 130(6): 1071-1082. |
Background
The TLR family of proteins plays a key role in innate immunity by detecting conserved microbial molecular patterns like lipoproteins, lipopolysaccharides, flagellin, and nucleic acids. These type I transmembrane glycoproteins feature a single transmembrane domain and a conserved intracellular domain. TLR2, often paired with TLR1 or TLR6, is crucial for recognizing microbial lipoproteins and lipopeptides, driving inflammatory responses. It's particularly important in combating tuberculosis. Overall, TLR2 is pivotal in multiple physiological processes and holds great promise as a therapeutic target. Developing TLR2-targeted drugs could significantly advance treatments for various diseases.
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SDS-PAGE
ELISA
Immobilized TLR2 Flag His tag, Human (SP17) (Cat. No. UA060021) at 2 μg/mL (100 μL/well) on a Nickel Coated plate can bind TLR2 Rabbit pAb (A2545) with EC50 of 0.91-1.20ug/mL.
