WB result of HIRA Recombinant Rabbit mAb
Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: HEK-293 whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Lane 3: K562 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 112 kDa
Observed MW: 112 kDa
HIRA Recombinant Rabbit mAb (S-1802-37)
HIRA Recombinant Rabbit mAb (S-1802-37)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | HIRA |
| Synonyms | Protein HIRA; TUP1-like enhancer of split protein 1; Tuple1 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q61666 |
| Clone Number | S-1802-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | HEK-293, HeLa, K562, F9 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
HIRA, or the Histone chaperone HIRA complex, is a crucial protein complex involved in chromatin remodeling and the regulation of gene expression. It plays a significant role in the deposition of the histone variant H3.3 into nucleosomes, which is essential for DNA replication, repair, and the maintenance of genomic integrity. HIRA is particularly important in embryonic stem cells, where it helps to control the activity of retrotransposons, thereby safeguarding the stability of the genome. Its function in these processes underscores the importance of HIRA in development and the prevention of diseases associated with genomic instability.
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Western Blot
WB result of HIRA Recombinant Rabbit mAb
Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: F9 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 112 kDa
Observed MW: 112 kDa
