Immobilized CD19 His Tag Protein, Human(UA011126) can bind Coltuximab. The EC50 for this effect is 5.205 ng/mL.
Anti-Human CD19 Monoclonal Antibody (Coltuximab)
Anti-Human CD19 Monoclonal Antibody (Coltuximab)
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Product Details
Product Details
Product Specification
| Host | Human |
| Antigen | CD19 |
| Synonyms | B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12 |
| Location | Cell membrane |
| Accession | P15391 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1 |
| Application | Blocking of CD19 signaling functional assays |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD19, also known as B-lymphocyte antigen CD19 or B-Lymphocyte Surface Antigen B4, is a 95 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is encoded by the CD19 gene. It is primarily expressed on all B lineage cells, from early pro-B cells to plasma cells, and plays a crucial role in B cell development, activation, and signaling. As a co-receptor, CD19 enhances signaling through the B cell receptor (BCR) complex, lowering the threshold for B cell activation and promoting B cell proliferation and differentiation. It forms a complex with CD21, CD81, and other proteins, which helps in the recognition of antigens tagged with complement and amplifies BCR signaling. CD19 is also a biomarker for B cell-related diseases and a target for immunotherapies, including monoclonal antibodies and CAR-T cell therapies, due to its consistent expression on B cells and B cell malignancies.
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ELISA
