Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD185 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2b, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ Antibody separately.
Rat Anti-Mouse CD185 Antibody (S-R600)
Rat Anti-Mouse CD185 Antibody (S-R600)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | Mouse CD185 |
| Synonyms | C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1 homolog; Cxcr5; Blr1; Gpcr6 |
| Location | Cell membrane |
| Accession | Q04683 |
| Clone Number | S-R600 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD185, also known as CXCR5 (C-X-C motif chemokine receptor 5), is a seven-transmembrane G protein-coupled receptor primarily expressed on mature B cells, follicular helper T cells (Tfh), and certain memory T cell subsets. It is essential for lymphocyte trafficking, particularly in directing T cells to B cell follicles within germinal centers in response to its ligand, CXCL13. CD185 plays a critical role in B cell maturation and the formation of high-affinity antibodies by facilitating interactions between Tfh cells and B cells. Additionally, it is involved in the regulation of neural stem cells and neuronal regeneration.
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