Flow cytometric analysis of collagenase-digested C57BL/6 mouse splenocytes labelling Mouse XCR1 antibody at 1/100 dilution (2 μg) / (Right panel) compared with a Mouse IgG2b, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD8 - Alexa Fluor® 647 Antibody separately.
Mouse Anti-Mouse XCR1 Antibody (S-R601)
Mouse Anti-Mouse XCR1 Antibody (S-R601)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | XCR1 |
| Synonyms | Chemokine XC receptor 1; Lymphotactin receptor; SCM1 receptor; XC chemokine receptor 1; mXCR1; Ccxcr1; Xcr1 |
| Location | Cell membrane |
| Accession | Q9R0M1 |
| Clone Number | S-R601 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | collagenase-digested C57BL/6 mouse splenocytes |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | Ms |
Background
XCR1 is a conserved, 37-kDa, seven-transmembrane, G-protein-coupled receptor selectively expressed on CD8α⁺ and CD103⁺ conventional dendritic cells; its only ligand, XCL1, is secreted by activated CD8⁺ T and NK cells to form a feed-forward loop that efficiently recruits antigen-bearing dendritic cells into draining lymph nodes, licenses cross-presentation, and amplifies cytotoxic immune responses against viruses and tumors, while genetic or antibody blockade of XCR1 impairs viral clearance, vaccine efficacy, and checkpoint-blockade-mediated anti-tumor immunity.
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