flow cytometric analysis of Human CD11b expression on human peripheral blood Leukocytes. Human peripheral blood Leukocytes were stained with SDT APC Mouse Anti-Human CD11b Antibody at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
APC Mouse Anti-Human CD11b Antibody (S-R404)
APC Mouse Anti-Human CD11b Antibody (S-R404)
Price:
Regular price
$131.00 SGD
Regular price
Sale price
$131.00 SGD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD11b |
| Synonyms | Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CR3A; ITGAM |
| Location | Cell membrane |
| Accession | P11215 |
| Clone Number | S-R404 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD11b, also known as integrin alpha M, is a transmembrane glycoprotein that pairs with CD18 to form the Mac-1 integrin, also referred to as complement receptor type 3 (CR3). It is predominantly expressed on the surface of myeloid cells, including monocytes, neutrophils, macrophages, and microglia. CD11b plays a crucial role in mediating cell adhesion and migration, facilitating the interaction between immune cells and their targets. It is involved in phagocytosis, the process by which cells engulf and eliminate foreign particles or debris. Additionally, CD11b acts as a receptor for complement C3bi, mediating complement-coated particle uptake, and it binds to various ligands such as intercellular adhesion molecules (ICAMs) and fibrinogen, contributing to cell-mediated cytotoxicity, chemotaxis, and immune cell activation.
Picture
Picture
FC
