Product Specification
| Host |
Rat |
| Antigen |
CD8α |
| Synonyms |
Lyt-2 |
| Immunogen |
Recombinant Protein |
| Location |
Cell membrane |
| Accession |
P01731 |
| Clone Number |
S-353-45 |
| Antibody Type |
Rat mAb |
| Isotype |
IgG1,λ |
| Application |
FCM |
| Reactivity |
Ms |
| Positive Sample |
BALB/c mouse splenocytes |
| Purification |
Protein G |
| Concentration |
0.1mg/ml |
| Conjugation |
Alexa Fluor® 700 |
| Physical Appearance |
Liquid |
| Storage Buffer |
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage |
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application |
dilution |
species |
| FCM |
5 μl per million cells in 100μl volume |
Ms |
Background
CD8a, also known as CD8α, is a molecular marker on the surface of T lymphocytes. It belongs to the family of leukocyte differentiation antigens and is primarily expressed on the surface of cytotoxic T lymphocytes (CTLs). CD8a plays a crucial role in immune responses related to cytotoxicity and local inflammation. It has the ability to bind to MHC class I molecules. The expression level of CD8 molecules undergoes changes during various stages of T cell differentiation, development, and in response to T cell stimuli. Additionally, CD8a is closely associated with autoimmune monitoring, humoral immune responses, and transplant reactions. For instance, CD8a can serve as a monitoring indicator for certain autoimmune diseases and plays a significant role in immunotherapy for anti-tumor and anti-viral treatments.
