Flow cytometric analysis of Mouse CD105 expression on bEnd.3 cells. Cells from the bEnd.3 (Mouse brain endothelioma, Right) or NIH/3T3 (Mouse embryonic fibroblast, Left) was stained with Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) and SDT Alexa Fluor® 647 Rat Anti-Mouse CD105 Antibody (Red line histogram) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rat Anti-Mouse CD105 Antibody (S-R529)
Alexa Fluor® 647 Rat Anti-Mouse CD105 Antibody (S-R529)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD105 |
| Synonyms | Endoglin; Cell surface MJ7/18 antigen; Edg; Eng |
| Location | Cell membrane |
| Accession | Q63961 |
| Clone Number | S-R529 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | bEnd.3 |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD105, also known as Endoglin, is a type I transmembrane glycoprotein and a component of the transforming growth factor-beta (TGF-β) receptor complex. It is highly expressed in proliferating endothelial cells and plays a crucial role in angiogenesis and vascular development. CD105 is upregulated in areas of active vascular growth, such as tumor tissues, wound healing sites, and inflamed tissues, making it a valuable marker for studying tumor-related angiogenesis. Additionally, it is involved in maintaining the integrity of the vascular system and regulating immune responses. In clinical applications, CD105 is used as a diagnostic marker for certain cancers and vascular diseases, and it is also a potential target for anti-angiogenic therapies.
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